To begin, we provide a concise summary of the fundamental definitions regarding our primary focus: histamine, naturally present in human, plant, and animal organisms.
Histamine is a biogenic amine and an essential mediator of the neuroimmunoendocrine system. It functions as a neurotransmitter in the brain and regulates various physiological processes in the human body, from gastric acid secretion to inflammatory and immune responses. Diamine oxidase, often abbreviated as DAO, is the main secretory enzyme responsible for the extracellular degradation and metabolism of histamine ingested through food. It is predominantly produced in the intestinal mucosa, as detailed in the scientific review by Laura Maintz and Natalija Novak published in The American Journal of Clinical Nutrition in 2007, and research by Martin Hrubisko and colleagues in the journal Nutrients in 2021.
In short, here we will understand the imbalance of this metabolism and learn how to restore equilibrium.
press
Press and information area for DAO Equilibrium - a communication, education, and solutions ecosystem dedicated to providing vital resources to address the high rate of global underdiagnosis of histamine imbalance.
News regarding corporate collaboration agreements, institutional cooperation, new editions of educational programmes, and the DAO Equilibrium Fellowship, among others.
TAO & DAO MAGAZINE
"Together for health. Stand with science". DAO Equilibrium adheres to the WHO campaign calling for global cooperation to achieve better health outcomes for everyone.
To this end, we focus Tao & Dao Magazine on updated content translated into accessible language concerning histamine imbalance and DAO enzyme deficiency.
#OneHealth, the theme of International Health Day 2026, has also become a keyword in our positioning towards eradicating the global underdiagnosis of this multisystemic metabolic syndrome.
In our "Symptoms", "Diagnostic Support", and "Equilibrium" columns, we publish articles and interviews with specialists. From the perspectives of nutrition, naturopathy, immunopsychology, and sports medicine, among others, we provide information on the best practices for managing this condition. We also speak with representatives from the nutraceutical, food, and gastronomic industries to bring you the latest word on food and dietary supplementation.
Symptoms
Diagnostic support
Equilibrium
We will know about the symptoms of food hypersensitivity resulting from histamine imbalance.
We will understand the scientific discoveries regarding this multisystemic metabolic syndrome and how to start a guided self-assessment.
We will learn about therapeutic nutrition, appropriate sports practice for muscle recovery, home gardening, and low-histamine cooking.
In the DAO Equilibrium apps section, you will find digital tools created to support sensitive individuals on their journey to histamine balance and for health professionals to use as aids in diagnosis and nutritional strategic planning.
These solutions include the Collaborative Map, listing points of sale with suitable low-histamine diet options; the "free-from" Product Price Index, which assists in dietary planning; and the Impact Observatory, which encourages public participation in raising awareness about this food hypersensitivity, among other applications.
dao equilibrium apps
Informational material
Save the link to this page to access periodic updates. Consult them whenever necessary and share them with others who may benefit from this information.
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Food lists for the selective low-histamine diet.
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Reports.
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Practical sheets.
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Database.
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Planners and others.
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